【団体名】：Cincinnati Children’s Hospital Medical Center Reproductive Science Center

【募集職種】：Postdoctoral Fellow

【募集分野・業務内容】：
　シンシナティ小児病院 生殖科学部門の Sudhansu K Dey labではポスドクを募集しています。Dey教授は雌性生殖系研究、特に子宮機能に着目した着床研究の世界的権威であり、主に子宮特異的KOマウスを用いて解析を行なっています。Dey教授はこれまで40年以上のキャリアの中で400本以上の論文を出版しており、Referenceにもある通り、ごく近年においてもHigh impact journalで精力的に論文を発表し続けています。

　今回は生物学、生理学、薬学あるいはその関連分野の専門性を有した博士号取得者(見込含)を募集します。
シンシナティ小児病院では顕微鏡コア、Flow Cytometoryコアなどの共同利用実験施設が充実しており、専門スタッフの指導のもと最新機器を利用し研究遂行可能です。
また、当研究施設はオハイオ州シンシナティに所在し、大都市部と比べ物価が安く暮らしやすい場所です。日本人PI・日本人ポスドクが同研究施設や隣接したUniversity of Cincinnatiに多数在籍し、日本人研究者のコミュニティも存在します。また、近隣市に日本語補修校も設置されているため、家族連れでも駐在しやすい環境です。
応募者の方は、過去の研究略歴や将来の研究の展望を添えた履歴書(Curriculum vitae)を添えて、Prof. Dey (SK.Dey@cchmc.org)もしくはDr. Xioafei Sun (xiaofei.sun@cchmc.org)まで直接ご連絡ください。

Dr. SK Dey group (Lova Riekert Chair and Professor of Pediatrics at Cincinnati Children’s Research Foundation) is recruiting a postdoctoral fellow.Dr. Dey has been studying in the field of female reproduction for more than 40 years. He was awarded the Carl G. Hartman award (2008), the most prestigious award in reproduction field, and the IVI Foundation Award for the Best Clinical Research Record in Reproductive Medicine (2009). Pregnancy is a complex process, comprising ovulation, fertilization, preimplantation embryo development, oviductal embryo transport, embryo implantation, uterine decidualization, placentation and parturition. They are all critical, and failure at any of these events compromises pregnancy outcome. Implantation is the first direct encounter between the embryo and mother, while parturition is the end of this encounter, although soluble factors from the uterus and/or embryo influence the embryo-uterine dialogue prior to implantation. Therefore, implantation and parturition conceptually, physiologically and clinically are two distinct conundrums with different molecular and genetic signatures. While implantation failure is a significant cause of infertility and a clinical issue in IVF programs, preterm birth and prematurity, on the other hand, are problems that continue beyond birth, posing a huge long-term social and economic liability. Dr. Dey has published more than 400 articles in respected journals, including Cell, Nature, Science, Nature Medicine, JCI, Genes&Development, Nature review Genetics, PNAS, Nat Communication and Development. Currently, Dr. Dey is serving JCI and Science Translational medicine as a consulting expert.

Reference:
Matsuo, M; Yuan, J; Kim, YS; Dewar, A; Fujita, H; Dey, SK; Sun, X. Targeted depletion of uterine glandular Foxa2 induces embryonic diapause in mice. eLife. 2022; 11.

Kim, YS; Li, Y; Yuan, J; Borg, JP; Sun, X; Dey, SK. Cannabinoid and planar cell polarity signaling converges to direct placentation. Proceedings of the National Academy of Sciences of the United States of America. 2021; 118.

Yuan, J; Aikawa, S; Deng, W; Bartos, A; Walz, G; Grahammer, F; Huber, TB; Sun, X; Dey, SK. Primary decidual zone formation requires Scribble for pregnancy success in mice. Nature Communications. 2019; 10.

Yuan, J; Deng, W; Cha, J; Sun, X; Borg, J; Dey, SK. Tridimensional visualization reveals direct communication between the embryo and glands critical for implantation. Nature Communications. 2018; 9.

Deng W; Cha J; Yuan J; Haraguchi H; Bartos A; Leishman E; Viollet B; Bradshaw HB; Hirota Y; Dey SK. p53 coordinates decidual sestrin 2/AMPK/mTORC1 signaling to govern parturition timing. J Clin Invest. 2016;126

【応募資格】：
MAJOR DUTIES AND RESPONSIBILITIES:
•Design, execute, and record laboratory experiments, and analyze the data.
•Research and improve current methods and evaluate innovative techniques. Implement this knowledge in the Division/Department.
•Present research at laboratory meetings, journal clubs, seminars, and meetings.
•Draft, write, and edit scientific reports, papers, journal articles, abstracts, and grants.
•Attend required Cincinnati Children’s training sessions and ensure regulatory compliance with all policies and procedures.
•Perform other duties as assigned.

Qualifications: Doctoral degree in Biological Sciences, Physiology, Pharmacology or related field.

【提出書類】：
応募者の方は、以下1.〜4.を英文にて一つのA4用紙1枚相当のpdfにまとめ、下記の連絡先メールアドレスに送付ください。
1. 履歴書
2. 研究業績目録
3. これまでの研究のまとめ
4. 推薦書 (推薦者の連絡先を明記すること)

Contact:
Prof. Dey: sk.dey@cchmc.org
Dr. Sun: xiaofei.sun@cchmc.org

【着任時期】：可能な限り早期、相談可

【勤務形態】：常勤

【勤務地】：Cincinnati, OH, USA

【処遇・待遇】：Compensation: $56K+/year with medical and dental insurance.

【応募締切日】：2023/10/31

【参考URL】：https://www.cincinnatichildrens.org/research/divisions/r/reproductive-sciences/labs/dey

■問い合わせ先
【担当者名】：Sudhansu K Dey: Xiaofei Sun
【TEL】：+1-513-803-1158
【E-mailアドレス】：sk.dey@cchmc.org